Everything about Gnrh Analog totally explained
A
gonadotropin-releasing hormone analogue, also known as a
GnRH analogue, (sometimes
analog) is a synthetic
peptide drug modeled after the human
hypothalamic gonadotropin-releasing hormone (GnRH). A GnRH analogue is designed to interact with the GnRH
receptor and modify the release of
pituitary gonadotropins
FSH and
LH for therapeutic purposes. Shortly after the discovery of GnRH by
Nobel laureates Guillemin and
Schally researchers tried to modify the GnRH decapeptide with the intent to synthesize stimulating and blocking variants.
Two types of analogues have to be distinguished:
Agonists
A gonadotropin-releasing hormone agonist (GnRH agonist) is an analogue that activates the GnRH receptor resulting in increased secretion of FSH and LH. Initially it was thought that agonists would be able to be used as potent and prolonged stimulators of pituitary gonadotropin release, but it was soon recognized that agonists, after their initial stimulating action – termed a “flare” effect -, eventually caused a paradoxical and sustained drop in gonadotropin secretion. This second effect was termed “downregulation” and can be observed after about 10 days. While this phase is reversible it can be maintained with further GnRH agonist use for a long time.
Antagonists
A gonadotropin-releasing hormone antagonist (GnRH antagonist) is an analogue that blocks the GnRH receptor resulting in an immediate drop in gonadotropin (FSH, LH) secretion. The GnRH antagonist is primarily used in
IVF treatments to block natural ovulation.
All GnRH analogues are contraindicated in pregnancy (
pregnancy category X).
xx
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